Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | AU565 | 100.0 | nM | 24 | hr | 453.87 | 115.71 | p-4EBP1 | 166.38 | |
| GSK1059615 | AU565 | 100.0 | nM | 6 | hr | 260.75 | 64.41 | p-4EBP1 | 85.16 | |
| Torkinib | AU565 | 31.6 | nM | 24 | hr | 395.95 | 75.66 | p-4EBP1 | 84.49 | |
| Torkinib | AU565 | 31.6 | nM | 6 | hr | 251.01 | 49.47 | p-4EBP1 | 31.81 | |
| Gefitinib | AU565 | 0 (control) | 6 | hr | 234.75 | 54.33 | p-Akt | 24.82 | |