Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | T47D | 1.0 | nM | 6 | hr | 102.89 | 57.24 | p-S6 | 73.06 | |
| Dactolisib | T47D | 1.0 | nM | 24 | hr | 140.57 | 100.31 | p-S6 | 315.62 | |
| Gefitinib | T47D | 3.16 | nM | 24 | hr | 165.53 | 122.53 | p-S6 | 338.85 | |
| Torkinib | T47D | 0.422 | nM | 6 | hr | 188.74 | 98.75 | p-S6 | 471.80 | |
| GSK1059615 | T47D | 3.16 | nM | 24 | hr | 161.44 | 94.40 | p-Akt | 65.08 | |
| Gefitinib | T47D | 1.0 | uM | 6 | hr | 160.75 | 102.16 | p-Akt | 104.17 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 90.30 | 37.28 | p-Akt | 6.14 | |
| Gefitinib | T47D | 3.16 | uM | 6 | hr | 155.01 | 95.03 | p-Akt | 100.54 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 149.87 | 76.09 | p-Akt | 15.96 | |
| Gefitinib | T47D | 1.0 | uM | 24 | hr | 156.94 | 108.01 | p-Akt | 80.72 | |
| GSK1059615 | T47D | 1.0 | uM | 6 | hr | 158.41 | 63.89 | p-Akt | 21.30 | |
| Torkinib | T47D | 562.0 | nM | 24 | hr | 119.35 | 36.17 | p-Akt | 13.61 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 138.60 | 47.77 | p-Akt | 13.85 | |
| Triciribine | T47D | 1.0 | uM | 24 | hr | 168.38 | 70.15 | p-Akt | 36.06 | |
| Gefitinib | T47D | 3.16 | nM | 6 | hr | 181.54 | 100.89 | p-Akt | 103.21 | |
| MK2206 | T47D | 1.0 | nM | 6 | hr | 99.92 | 49.23 | p-4EBP1 | 113.45 | |
| Gefitinib | T47D | 3.16 | nM | 24 | hr | 164.50 | 108.71 | p-Akt | 78.14 | |
| Triciribine | T47D | 1.0 | uM | 6 | hr | 119.47 | 61.20 | p-Akt | 13.24 | |
| Torkinib | T47D | 0.422 | nM | 6 | hr | 170.81 | 90.25 | p-Akt | 78.90 | |
| Dactolisib | T47D | 1.0 | nM | 6 | hr | 95.66 | 52.97 | p-4EBP1 | 132.08 | |
| Torkinib | T47D | 0.422 | nM | 24 | hr | 165.87 | 94.49 | p-Akt | 59.39 | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 115.16 | 30.63 | p-Akt | 12.53 | |
| GSK1059615 | T47D | 3.16 | nM | 6 | hr | 165.75 | 87.48 | p-Akt | 92.56 | |
| Dactolisib | T47D | 3.16 | nM | 6 | hr | 94.68 | 57.90 | p-S6 | 78.09 | |
| Triciribine | T47D | 3.16 | nM | 24 | hr | 152.67 | 103.52 | p-S6 | 378.65 | |