Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | T47D | 2.37 | uM | 24 | hr | 113.67 | 41.15 | p-4EBP1 | 11.39 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 133.77 | 58.56 | p-Akt | 14.98 | |
| Gefitinib | T47D | 31.6 | nM | 6 | hr | 167.03 | 97.05 | p-Akt | 101.76 | |
| Gefitinib | T47D | 31.6 | nM | 24 | hr | 155.72 | 101.88 | p-Akt | 76.48 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 157.46 | 86.43 | p-Akt | 48.47 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 144.08 | 65.96 | p-Akt | 33.04 | |
| GSK1059615 | T47D | 31.6 | nM | 6 | hr | 168.17 | 85.32 | p-Akt | 73.10 | |
| GSK1059615 | T47D | 31.6 | nM | 24 | hr | 155.80 | 86.40 | p-Akt | 49.01 | |
| MK2206 | T47D | 31.6 | nM | 6 | hr | 105.79 | 49.19 | p-Akt | 9.27 | |
| MK2206 | T47D | 31.6 | nM | 24 | hr | 146.52 | 86.34 | p-Akt | 26.31 | |
| Triciribine | T47D | 31.6 | nM | 6 | hr | 111.54 | 58.38 | p-Akt | 17.15 | |
| Triciribine | T47D | 31.6 | nM | 24 | hr | 173.98 | 88.45 | p-Akt | 50.47 | |
| Dactolisib | T47D | 31.6 | nM | 6 | hr | 88.70 | 45.24 | p-Akt | 10.08 | |
| Dactolisib | T47D | 31.6 | nM | 24 | hr | 113.51 | 47.76 | p-Akt | 26.04 | |
| MK2206 | T47D | 316.0 | nM | 6 | hr | 106.17 | 51.36 | p-Akt | 7.32 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 153.21 | 83.29 | p-Akt | 22.78 | |
| Gefitinib | T47D | 10.0 | uM | 24 | hr | 132.66 | 79.82 | p-4EBP1 | 376.65 | |
| Gefitinib | T47D | 316.0 | nM | 24 | hr | 159.76 | 114.64 | p-Akt | 81.98 | |
| GSK1059615 | T47D | 10.0 | uM | 6 | hr | 167.66 | 60.97 | p-4EBP1 | 61.20 | |
| Gefitinib | T47D | 316.0 | nM | 6 | hr | 157.11 | 101.80 | p-Akt | 102.46 | |
| MK2206 | T47D | 10.0 | uM | 6 | hr | 108.84 | 30.13 | p-4EBP1 | 73.21 | |
| GSK1059615 | T47D | 316.0 | nM | 6 | hr | 155.22 | 70.63 | p-Akt | 39.74 | |
| GSK1059615 | T47D | 316.0 | nM | 24 | hr | 145.35 | 43.87 | p-Akt | 26.14 | |
| Triciribine | T47D | 0 (control) | 24 | hr | 178.57 | 98.11 | p-S6 | 353.20 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 93.67 | 36.69 | p-S6 | 48.97 | |