HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Torkinib	MCF 10A	0.1	nM	24	hr	342.29	124.00	p-Akt	50.29
GSK1059615	MCF 10A	1.0	nM	6	hr	470.40	164.01	p-Akt	53.70
GSK1059615	MCF 10A	1.0	nM	24	hr	382.76	126.38	p-Akt	50.94
MK2206	MCF 10A	1.0	nM	6	hr	436.98	158.45	p-Akt	51.09
MK2206	MCF 10A	1.0	nM	24	hr	309.88	125.31	p-Akt	42.87
Triciribine	MCF 10A	1.0	nM	6	hr	439.88	158.37	p-Akt	51.51
Triciribine	MCF 10A	1.0	nM	24	hr	311.02	118.46	p-Akt	43.92
Dactolisib	MCF 10A	1.0	nM	6	hr	437.12	174.36	p-Akt	52.90
Dactolisib	MCF 10A	1.0	nM	24	hr	332.80	131.47	p-Akt	43.15
Gefitinib	T47D	1.0	nM	6	hr	174.36	98.22	p-Akt	105.50
Gefitinib	T47D	1.0	nM	24	hr	158.15	112.49	p-Akt	78.61
Torkinib	T47D	0.1	nM	6	hr	173.65	92.27	p-Akt	90.58
Torkinib	T47D	0.1	nM	24	hr	159.19	92.25	p-Akt	63.92
GSK1059615	T47D	1.0	nM	6	hr	177.09	87.31	p-Akt	93.26
GSK1059615	T47D	1.0	nM	24	hr	163.58	90.72	p-Akt	66.78
MK2206	T47D	1.0	nM	6	hr	94.42	35.53	p-Akt	13.06
MK2206	T47D	1.0	nM	24	hr	161.37	97.31	p-Akt	58.78
Triciribine	T47D	1.0	nM	6	hr	96.98	46.31	p-Akt	19.11
Triciribine	T47D	1.0	nM	24	hr	146.78	89.33	p-Akt	59.46
Dactolisib	T47D	1.0	nM	6	hr	90.24	35.16	p-Akt	13.70
Dactolisib	T47D	1.0	nM	24	hr	138.24	90.29	p-Akt	47.16
Gefitinib	AU565	3.16	nM	6	hr	308.09	68.07	p-Akt	33.62
Gefitinib	AU565	3.16	nM	24	hr	586.23	125.39	p-Akt	136.14
Torkinib	AU565	0.422	nM	6	hr	269.85	59.34	p-Akt	25.74
Torkinib	AU565	0.422	nM	24	hr	481.77	110.68	p-Akt	88.17

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