Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | T47D | 3.16 | uM | 24 | hr | 185.88 | 61.96 | p-S6 | 7.51 | |
| MK2206 | T47D | 3.16 | uM | 6 | hr | 111.23 | 34.13 | p-S6 | 29.78 | |
| MK2206 | T47D | 3.16 | uM | 24 | hr | 151.33 | 46.28 | p-S6 | 26.26 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 104.79 | 44.18 | p-S6 | 46.47 | |
| Triciribine | T47D | 3.16 | uM | 24 | hr | 163.59 | 74.05 | p-S6 | 431.08 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 99.22 | 33.03 | p-S6 | 4.39 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 125.24 | 44.30 | p-S6 | 5.70 | |
| Gefitinib | AU565 | 10.0 | uM | 6 | hr | 191.61 | 37.14 | p-S6 | 9.87 | |
| Gefitinib | AU565 | 10.0 | uM | 24 | hr | 324.29 | 68.22 | p-S6 | 10.81 | |
| Torkinib | AU565 | 10.0 | uM | 6 | hr | 184.42 | 33.37 | p-S6 | 10.58 | |
| Torkinib | AU565 | 10.0 | uM | 24 | hr | 413.48 | 73.58 | p-S6 | 13.45 | |
| GSK1059615 | AU565 | 10.0 | uM | 6 | hr | 189.34 | 37.66 | p-S6 | 13.76 | |
| GSK1059615 | AU565 | 10.0 | uM | 24 | hr | 304.47 | 67.62 | p-S6 | 7.51 | |
| MK2206 | AU565 | 10.0 | uM | 6 | hr | 280.60 | 56.08 | p-S6 | 32.77 | |
| MK2206 | AU565 | 10.0 | uM | 24 | hr | 328.96 | 67.29 | p-S6 | 51.18 | |
| Triciribine | AU565 | 10.0 | uM | 6 | hr | 272.99 | 60.30 | p-S6 | 45.49 | |
| Triciribine | AU565 | 10.0 | uM | 24 | hr | 427.95 | 65.65 | p-S6 | 116.70 | |
| Dactolisib | AU565 | 10.0 | uM | 6 | hr | 189.90 | 41.38 | p-S6 | 10.76 | |
| Dactolisib | AU565 | 10.0 | uM | 24 | hr | 505.22 | 65.42 | p-S6 | 10.52 | |
| Gefitinib | HCC1954 | 10.0 | uM | 6 | hr | 135.08 | 44.80 | p-S6 | 62.46 | |
| Gefitinib | HCC1954 | 10.0 | uM | 24 | hr | 303.53 | 87.72 | p-S6 | 385.00 | |
| Torkinib | HCC1954 | 10.0 | uM | 6 | hr | 185.58 | 33.15 | p-S6 | 8.81 | |
| Torkinib | HCC1954 | 10.0 | uM | 24 | hr | 238.58 | 54.81 | p-S6 | 7.21 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 6 | hr | 293.44 | 62.09 | p-S6 | 10.04 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 24 | hr | 326.12 | 62.00 | p-S6 | 11.15 | |