HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Dactolisib	AU565	100.0	nM	6	hr	269.91	55.81	p-S6	12.02
Dactolisib	AU565	100.0	nM	24	hr	393.25	63.31	p-S6	12.24
Gefitinib	HCC1954	100.0	nM	6	hr	213.10	78.34	p-S6	177.32
Gefitinib	HCC1954	100.0	nM	24	hr	269.55	117.84	p-S6	318.48
Torkinib	HCC1954	31.6	nM	6	hr	161.40	30.73	p-S6	30.08
Torkinib	HCC1954	31.6	nM	24	hr	266.32	99.88	p-S6	438.02
GSK1059615	HCC1954	100.0	nM	6	hr	419.56	95.98	p-S6	356.54
GSK1059615	HCC1954	100.0	nM	24	hr	305.48	111.20	p-S6	386.05
MK2206	HCC1954	100.0	nM	6	hr	288.98	84.39	p-S6	370.50
MK2206	HCC1954	100.0	nM	24	hr	261.03	111.95	p-S6	276.13
Triciribine	HCC1954	100.0	nM	6	hr	279.96	90.92	p-S6	518.11
Triciribine	HCC1954	100.0	nM	24	hr	261.09	103.43	p-S6	332.12
Dactolisib	HCC1954	100.0	nM	6	hr	202.83	71.94	p-S6	11.00
Dactolisib	HCC1954	100.0	nM	24	hr	295.11	86.73	p-S6	12.20
Gefitinib	MCF 10A	100.0	nM	6	hr	350.57	171.33	p-S6	499.12
Gefitinib	MCF 10A	100.0	nM	24	hr	416.72	200.10	p-S6	651.75
Torkinib	MCF 10A	31.6	nM	6	hr	483.85	173.27	p-S6	648.81
Torkinib	MCF 10A	31.6	nM	24	hr	530.47	184.23	p-S6	699.60
GSK1059615	MCF 10A	100.0	nM	6	hr	360.15	184.01	p-S6	712.09
GSK1059615	MCF 10A	100.0	nM	24	hr	401.51	187.40	p-S6	583.76
MK2206	MCF 10A	100.0	nM	6	hr	374.66	157.98	p-S6	523.21
MK2206	MCF 10A	100.0	nM	24	hr	285.48	156.23	p-S6	281.30
Triciribine	MCF 10A	100.0	nM	6	hr	378.65	159.58	p-S6	526.92
Triciribine	MCF 10A	100.0	nM	24	hr	290.10	152.22	p-S6	274.55
Dactolisib	MCF 10A	100.0	nM	6	hr	362.69	127.56	p-S6	369.43

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