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Library of Integrated Network-based Cellular Signatures
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AZD 5438 KINOMEscan
- Dataset (ID:20135)
Detail
Small Molecules Studied
Proteins Studied
Data Columns
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Small molecules
Proteins
10158:AZD 5438
200001:AAK1
200004:ABL1(E255K)-phosphorylated
200006:ABL1(F317I)-nonphosphorylated
200007:ABL1(F317I)-phosphorylated
200009:ABL1(F317L)-nonphosphorylated
200010:ABL1(F317L)-phosphorylated
200012:ABL1(H396P)-nonphosphorylated
200013:ABL1(H396P)-phosphorylated
200015:ABL1(M351T)-phosphorylated
200017:ABL1(Q252H)-nonphosphorylated
200018:ABL1(Q252H)-phosphorylated
200020:ABL1(T315I)-nonphosphorylated
200021:ABL1(T315I)-phosphorylated
200023:ABL1(Y253F)-phosphorylated
200024:ABL1-nonphosphorylated
200025:ABL1-phosphorylated
200026:ABL2
200027:ACVR1
200028:ACVR1B
200029:ACVR2A
200030:ACVR2B
200031:ACVRL1
200032:ADCK3
200033:ADCK4
200034:AKT1
200035:AKT2
200036:AKT3
200037:ALK
200038:AMPK-alpha1
200039:AMPK-alpha2
200040:ANKK1
200041:NUAK1
200042:M3K5
200043:M3K6
200044:AURKA
200045:AURKB
200046:AURKC
200047:AXL
200048:BIKE
200049:BLK
200050:BMPR1A
200051:BMPR1B
200052:BMPR2
200053:BMX
200054:BRAF
200055:BRAF(V600E)
200056:PTK6
200057:BRSK1
200058:BRSK2
200059:BTK
200060:CAMK1
200061:CAMK1D
200062:CAMK1G
200063:CAMK2A
200064:CAMK2B
200065:KCC2D
200066:CAMK2G
200067:KCC4
200068:KKCC1
200069:CAMKK2
200070:CASK
200071:CDC2L1
200072:CDC2L2
200073:CDC2L5
200074:CDK11
200075:CDK2
200076:CDK3
200077:CDK4-cyclinD1
200078:CDK4-cyclinD3
200079:CDK5
200080:CDK7
200081:CDK8
200082:CDK9
200083:CDKL1
200084:CDKL2
200085:CDKL3
200086:CDKL5
200087:CHEK1
200088:CHK2
200089:CIT
200090:CLK1
200091:CLK2
200092:CLK3
200093:CLK4
200094:CSF1R
200095:CSK
200096:CSNK1A1
200097:CSNK1A1L
200098:CSNK1D
200099:CSNK1E
200100:KC1G1
200101:KC1G2
200102:CSNK1G3
200103:CSNK2A1
200104:CSNK2A2
200105:CTK
200106:DAPK1
200107:DAPK2
200108:DAPK3
200109:DCLK1
200110:DCAMKL2
200111:DCAMKL3
200112:DDR1
200113:DDR2
200114:M3K12
200115:DMPK
200116:DMPK2
200117:DRAK1
200118:DRAK2
200119:DYRK1A
200120:DYRK1B
200121:DYRK2
200122:EGFR
200123:EGFR(E746-A750del)
200124:EGFR(G719C)
200125:EGFR(G719S)
200126:EGFR(L747-E749del, A750P)
200127:EGFR(L747-S752del, P753S)
200128:EGFR(L747-T751del,Sins)
200129:EGFR(L858R)
200130:EGFR(L858R,T790M)
200131:EGFR(L861Q)
200132:EGFR(S752-I759del)
200133:EGFR(T790M)
200134:EIF2AK1
200135:EPHA1
200136:EPHA2
200137:EPHA3
200138:EPHA4
200139:EPHA5
200140:EPHA6
200141:EPHA7
200142:EPHA8
200143:EPHB1
200144:EPHB2
200145:EPHB3
200146:EPHB4
200147:EPHB6
200148:ERBB2
200149:ERBB3
200150:ERBB4
200151:MK03
200152:MK01
200153:ERK3
200154:ERK4
200155:ERK5
200156:ERK8
200157:ERN1
200158:FAK1
200159:FER
200160:FES
200161:FGFR1
200162:FGFR2
200163:FGFR3
200164:FGFR3(G697C)
200165:FGFR4
200166:FGR
200167:VGFR1
200168:FLT3
200169:FLT3(D835H)
200170:FLT3(D835Y)
200171:FLT3(ITD)
200172:FLT3(K663Q)
200173:FLT3(N841I)
200174:FLT3(R834Q)
200175:FLT4
200176:FRK
200177:FYN
200178:GAK
200179:GCN2(Kin.Dom.2,S808G)
200180:GRK1
200181:GRK4
200182:GRK7
200183:GSK3A
200184:GSK3B
200185:HCK
200186:HIPK1
200187:HIPK2
200188:HIPK3
200189:HIPK4
200190:M4K1
200191:HUNK
200192:ICK
200193:IGF1R
200194:IKKA
200195:IKKB
200196:IKKE
200197:INSR
200198:INSRR
200199:IRAK1
200200:IRAK3
200201:IRAK4
200202:ITK
200203:JAK1(JH1domain-catalytic)
200204:JAK1(JH2domain-pseudokinase)
200207:JAK2(JH1domain-catalytic)
200209:JAK3(JH1domain-catalytic)
200211:JNK1
200212:MK09
200213:JNK3
200214:KIT
200215:KIT(A829P)
200216:KIT(D816H)
200217:KIT(D816V)
200218:KIT(L576P)
200219:KIT(V559D)
200220:KIT(V559D,T670I)
200221:KIT(V559D,V654A)
200222:LATS1
200223:LATS2
200224:LCK
200225:LIMK1
200226:LIMK2
200227:LKB1
200228:LOK
200229:LRRK2
200230:LRRK2(G2019S)
200231:LTK
200232:LYN
200233:M3K13
200234:MAK
200235:MAP3K1
200236:MAP3K15
200237:M3K2
200238:MAP3K3
200239:MAP3K4
200240:MAP4K2
200241:M4K3
200242:MAP4K4
200243:MAP4K5
200244:MAPKAPK2
200245:MAPKAPK5
200246:MARK1
200247:MARK2
200248:MARK3
200249:MARK4
200250:MAST1
200251:MP2K1
200252:MP2K2
200253:MP2K3
200254:MP2K4
200255:MP2K5
200256:MP2K6
200257:MELK
200258:MERTK
200259:MET
200260:MET(M1250T)
200261:MET(Y1235D)
200262:MINK
200263:MP2K7
200264:MKNK1
200265:MKNK2
200266:MLCK
200267:MLK1
200268:MLK2
200269:MLK3
200270:MRCKA
200271:MRCKB
200272:MST1
200273:MST1R
200274:MST2
200275:MST3
200276:MST4
200277:MTOR
200278:MUSK
200279:MYLK
200280:MYLK2
200281:MYLK4
200282:MYO3A
200283:MYO3B
200284:NDR1
200285:NDR2
200286:NEK1
200287:NEK11
200288:NEK2
200289:NEK3
200290:NEK4
200291:NEK5
200292:NEK6
200293:NEK7
200294:NEK9
200295:NIM1
200296:NLK
200297:OSR1
200298:MK14
200299:MK11
200300:MK13
200301:MK12
200302:PAK1
200303:PAK2
200304:PAK3
200305:PAK4
200306:PAK6
200307:PAK7
200309:CDK16
200310:PCTK2
200311:PCTK3
200312:PGFRA
200313:PGFRB
200314:PDPK1
200315:PFCDPK1(P.falciparum)
200316:PFPK5(P.falciparum)
200317:CDK15
200318:CDK14
200319:PHKG1
200320:PHKG2
200321:PIK3C2B
200322:PIK3C2G
200323:PIK3CA
200324:PIK3CA(C420R)
200325:PIK3CA(E542K)
200326:PIK3CA(E545A)
200327:PIK3CA(E545K)
200328:PIK3CA(H1047L)
200329:PIK3CA(H1047Y)
200330:PIK3CA(I800L)
200331:PIK3CA(M1043I)
200332:PIK3CA(Q546K)
200333:PIK3CB
200334:PIK3CD
200335:PIK3CG
200336:PIK4CB
200337:PIM1
200338:PIM2
200339:PIM3
200340:PIP5K1A
200341:PIP5K1C
200342:PIP5K2B
200343:PI42C
200344:PKAC-alpha
200345:PKAC-beta
200346:PKMYT1
200347:PKN1
200348:PKN2
200349:PKNB(M.tuberculosis)
200350:PLK1
200351:PLK2
200352:PLK3
200353:PLK4
200354:KPCD
200355:KPCE
200356:KPCL
200357:KPCI
200358:KPCT
200359:KPCD1
200360:KPCD2
200361:KPCD3
200362:KGP1
200363:KGP2
200364:PRKR
200365:PRKX
200366:PRP4
200367:FAK2
200368:SIK3
200369:RAF1
200370:RET
200371:RET(M918T)
200372:RET(V804L)
200373:RET(V804M)
200374:RIOK1
200375:RIOK2
200376:RIOK3
200377:RIPK1
200378:RIPK2
200379:RIPK4
200380:RIPK5
200381:ROCK1
200382:ROCK2
200383:ROS1
200390:RPS6KA4(Kin.Dom.1-N-terminal)
200392:RPS6KA4(Kin.Dom.2-C-terminal)
200394:RPS6KA5(Kin.Dom.1-N-terminal)
200396:RPS6KA5(Kin.Dom.2-C-terminal)
200399:RSK1(Kin.Dom.1-N-terminal)
200400:RSK1(Kin.Dom.2-C-terminal)
200401:RSK2(Kin.Dom.1-N-terminal)
200402:RSK3(Kin.Dom.1-N-terminal)
200403:RSK3(Kin.Dom.2-C-terminal)
200404:RSK4(Kin.Dom.1-N-terminal)
200405:RSK4(Kin.Dom.2-C-terminal)
200406:S6K1
200407:SBK1
200408:SgK110
200409:SGK3
200410:SIK1
200411:SIK2
200412:SLK
200413:SNARK
200414:SNRK
200415:SRC
200416:SRMS
200417:SRPK1
200418:SRPK2
200419:SRPK3
200420:STK16
200421:STK33
200422:STK35
200423:STK36
200424:STK39
200425:SYK
200426:TAK1
200427:TAOK1
200428:TAOK2
200429:TAOK3
200430:TBK1
200431:TEC
200432:TESK1
200433:TGFBR1
200434:TGFBR2
200435:TIE1
200436:TIE2
200437:TLK1
200438:TLK2
200439:TNIK
200440:TNK1
200441:TNK2
200442:TNNI3K
200443:TRKA
200444:TRKB
200445:TRKC
200446:TRPM6
200447:TSSK1
200448:TTK
200449:TXK
200450:TYK2(JH1domain-catalytic)
200451:TYK2(JH2domain-pseudokinase)
200454:TYRO3
200455:ULK1
200456:ULK2
200457:ULK3
200458:VGFR2
200459:VRK2
200460:WEE1
200461:WEE2
200462:YANK1
200463:YANK2
200464:YANK3
200465:YES
200466:YSK1
200467:YSK4
200468:MLTK
200469:ZAP70
200470:BUB1
200471:CSF1R-autoinhibited
200472:FLT3-autoinhibited
200473:HASP
200474:KIT-autoinhibited
200475:RSK2(Kin.Dom.2-C-terminal)
200476:SGK1
200477:WNK1
200478:WNK3
200479:ALK(C1156Y)
200480:ALK(L1196M)
200481:NEK10
201107:MAP3K14
201108:SGK2
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Small Molecule
Protein
% Control
Assay compound conc
Conc unit
AZD 5438
YANK2
100.0
10
uM
AZD 5438
YANK3
100.0
10
uM
AZD 5438
YES
64.0
10
uM
AZD 5438
YSK1
7.4
10
uM
AZD 5438
YSK4
0.0
10
uM
AZD 5438
ZAP70
41.0
10
uM
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