Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Trichostatin A | HCC1954 | -2.3010 | 0.9200 | -4.8680 | -4.8614 | -5.0142 | 1.9125 | 0.0223 | 0.0223 | 4.5927 |
| Trichostatin A | HCC202 | -2.3010 | 0.9946 | -5.6060 | -5.6001 | -5.9612 | 2.1550 | 0.0149 | 0.0149 | 3.7975 |
| Trichostatin A | HCC38 | -2.3010 | 0.9816 | -5.1470 | -5.1397 | -5.2478 | 3.0035 | 0.0253 | 0.0253 | 4.5603 |
| Trichostatin A | HCC70 | -2.3010 | 0.9937 | -4.6980 | -4.6943 | -4.8885 | 2.4470 | 0.0104 | 0.0104 | 5.1089 |
| Trichostatin A | Hs 578T | -2.3010 | 0.9769 | -4.7195 | -4.7134 | -4.7692 | 2.8145 | 0.0120 | 0.0120 | 5.2163 |
| Trichostatin A | MB 157 | -2.3010 | 0.9928 | -4.9680 | -4.9666 | -5.0738 | 1.7480 | 0.0032 | 0.0032 | 4.5977 |
| Trichostatin A | MDA-MB-134-VI | -2.3010 | 0.9556 | -4.9020 | -4.8003 | -5.2452 | 1.8090 | 0.1660 | 0.1664 | 5.4139 |
| Trichostatin A | MDA-MB-157 | -2.3010 | 0.9870 | -4.5220 | -4.5205 | -4.7920 | 2.0590 | 0.0060 | 0.0060 | 5.2276 |
| Trichostatin A | MDA-MB-175-VII | -2.3010 | 0.9816 | -4.6785 | -4.6297 | -5.2778 | 1.0380 | 0.0537 | 0.0569 | 5.1994 |
| Trichostatin A | MDA-MB-361 | -2.3010 | 0.9900 | -4.9720 | -4.9657 | -5.0913 | 3.4660 | 0.0134 | 0.0134 | 4.7595 |
| Trichostatin A | MDA-MB-436 | -2.3010 | 0.9766 | -4.7150 | -4.6140 | -4.7300 | 2.4220 | 0.2155 | 0.2155 | 5.7445 |
| Trichostatin A | MDA-MB-453 | -2.3010 | 0.9842 | -5.2355 | -5.2325 | -5.3569 | 2.3690 | 0.0136 | 0.0136 | 4.1238 |
| Trichostatin A | MDA-MB-468 | -2.3010 | 0.9883 | -4.7270 | -4.7209 | -4.7933 | 3.0220 | 0.0201 | 0.0201 | 5.1476 |
| Trichostatin A | T47D | -2.3010 | 0.9817 | -5.2390 | -5.2380 | -5.4822 | 1.6405 | 0.0020 | 0.0020 | 4.2513 |
| Trichostatin A | UACC-812 | -2.3010 | 0.9182 | -4.6925 | -4.6241 | -5.0743 | 1.4550 | 0.1017 | 0.1020 | 5.1885 |
| Trichostatin A | UACC-893 | -2.3010 | 0.9911 | -5.1235 | -5.1188 | -5.3317 | 2.9500 | 0.0192 | 0.0192 | 4.5560 |
| Trichostatin A | ZR-75-1 | -2.3010 | 0.9876 | -4.6200 | -4.5134 | -4.7797 | 1.9915 | 0.1905 | 0.1905 | 5.9452 |
| Trichostatin A | 184B5 | -2.3010 | 0.9838 | -4.1130 | -4.1130 | -4.3682 | 1.3820 | 0.0000 | 0.0035 | 5.8083 |
| Trichostatin A | HCC1187 | -2.3010 | 0.9821 | -5.2360 | -5.2325 | -5.3657 | 2.6760 | 0.0149 | 0.0149 | 4.3798 |
| Trichostatin A | MCF 10A | -2.3010 | 0.9831 | -4.7880 | -4.7805 | -4.8665 | 1.2940 | 0.0055 | 0.0061 | 5.0583 |
| Trichostatin A | MCF 10F | -2.3010 | 0.9375 | -4.0820 | -4.0665 | -4.2690 | 2.1330 | 0.0377 | 0.0378 | 6.5932 |
| Trichostatin A | SUM1315MO2 | -2.3010 | 0.9822 | -4.2110 | -4.1982 | -4.3426 | 3.0145 | 0.0404 | 0.0404 | 5.9435 |
| Trichostatin A | SUM149PT | -2.3010 | 0.9908 | -5.1320 | -5.1289 | -5.1832 | 4.0000 | 0.0124 | 0.0124 | 4.3968 |
| Trichostatin A | SUM159PT | -2.3010 | 0.9727 | -5.1850 | -5.1844 | -5.2343 | 1.5990 | 0.0000 | 0.0000 | 4.6160 |
| Trichostatin A | SUM185PE | -2.3010 | 0.9885 | -4.3890 | -4.3845 | -4.7450 | 1.8340 | 0.0097 | 0.0099 | 5.5155 |