LY294002 - Small Molecule (ID:10510-101)
| HMS LINCS ID: |
10510-101
|
| Name: | LY294002 |
| Alternative Names: | LY-294002 |
| LINCS ID: | |
| PubChem CID: | 3973 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 307.12 |
| InChi: | InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 |
| InChi Key: | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| SMILES: | C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-05-06 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
BRD2, BRD3, BRD4, CSNK2A1, CSNK2A2, GSK3A, GSK3B, MTOR, Pik3ca, PIK3CA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIM1, PRKDC | |
3 (equivalent to 1µM ≤ Kd < 10 µM) | CDK8, Mtor, PDE5A, PIK3C2B, PIK3R1, PIM3, PLK1 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10510-101-1 | LC Laboratories |
(equivalent to 100 nM ≤ Kd < 1µM)