GM6001 - Small Molecule (ID:10509-101)
| HMS LINCS ID: |
10509-101
|
| Name: | GM6001 |
| Alternative Names: | Ilomastat; Galardin; GM-6001 |
| LINCS ID: | |
| PubChem CID: | 132519 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 388.21 |
| InChi: | InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1 |
| InChi Key: | NITYDPDXAAFEIT-DYVFJYSZSA-N |
| SMILES: | CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-05-06 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ADAM12, ADAM17, ADAM9, MMP1, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP2, MMP26, MMP3, MMP7, MMP8, MMP9 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ADAM10 |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10509-101-1 | Enzo Life Sciences |
(Kd <100 nM)