Disulfiram - Small Molecule (ID:10507-999)
| HMS LINCS ID: |
10507-999
|
| Name: | Disulfiram |
| Alternative Names: | Tetraethylthiuram disulfide; TETD |
| LINCS ID: | |
| PubChem CID: | 3117 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 296.05 |
| InChi: | InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3 |
| InChi Key: | AUZONCFQVSMFAP-UHFFFAOYSA-N |
| SMILES: | CCN(CC)C(=S)SSC(=S)N(CC)CC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-05-06 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ALDH1A1, ALDH1A2, ALDH1B1, ALDH2, ALDH3B1, ALDH3B2 | |
3 (equivalent to 1µM ≤ Kd < 10 µM) | Htr1b, MAPK3, MAPT, MGLL |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10507-999-1 |
(equivalent to 100 nM ≤ Kd < 1µM)