JNJ-10198409 - Small Molecule (ID:10467-101)
| HMS LINCS ID: |
10467-101
|
| Name: | JNJ-10198409 |
| Alternative Names: | PDGF receptor tyrosine kinase inhibitor IV |
| LINCS ID: | |
| PubChem CID: | 9797370 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 325.12 |
| InChi: | InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) |
| InChi Key: | ZDNURMVOKAERHZ-UHFFFAOYSA-N |
| SMILES: | COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, PDGFRA, PDGFRB | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | FYN, LCK, SRC |
3 (equivalent to 1µM ≤ Kd < 10 µM) | CSNK1A1, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, FLT1, FLT4, KDR |
10 (confirmed non-binding) |
Batch Information for HMSL10467-101-1:
| HMS LINCS Batch ID: | 10467-101-1 |
| Provider: | EMD Millipore |
| Provider Batch ID: | D00168560 |
| Salt: | 101 |
| Molecular Formula: | C18H16FN3O2 |
| Molecular Weight: | 325.3 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-08-27 |
| Most Recent Update: | 2016-08-11 |
HMS QC Testing Events for HMSL10467-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 08/31/2015 | PASS | HMSL10467-101-1_LCMS.pdf |
(Kd <100 nM)