GTPL6019 - Small Molecule (ID:10464-101)
| HMS LINCS ID: |
10464-101
|
| Name: | GTPL6019 |
| Alternative Names: | PDGF receptor tyrosine kinase inhibitor III; 4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide |
| LINCS ID: | |
| PubChem CID: | 10907042 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 485.21 |
| InChi: | InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) |
| InChi Key: | INTPTKHSGKBHHW-UHFFFAOYSA-N |
| SMILES: | COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=O)NC4=CC=C(C=C4)OC5=CC=CC=C5)OC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
KIT, PDGFRA, PDGFRB | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | FLT3 |
10 (confirmed non-binding) |
Batch Information for HMSL10464-101-1:
| HMS LINCS Batch ID: | 10464-101-1 |
| Provider: | EMD Millipore |
| Provider Batch ID: | D00141875 |
| Salt: | 101 |
| Molecular Formula: | C27H27N5O4 |
| Molecular Weight: | 485.5 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-08-27 |
| Most Recent Update: | 2016-08-11 |
HMS QC Testing Events for HMSL10464-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 08/31/2015 | PASS | HMSL10464-101-1_LCMS.pdf |
(Kd <100 nM)