Taselisib - Small Molecule (ID:10445-101)
| HMS LINCS ID: |
10445-101
|
| Name: | Taselisib |
| Alternative Names: | GDC-0032; RG-7604 |
| LINCS ID: | LSM-45140 |
| PubChem CID: | 51001932 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 460.23 |
| InChi: | InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33) |
| InChi Key: | BEUQXVWXFDOSAQ-UHFFFAOYSA-N |
| SMILES: | CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2018-03-30 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
PIK3CA, PIK3CB, PIK3CD, PIK3CG | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | PIK3C2B, PIK3C3 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | MTOR, PRKDC |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20264 | Taselisib KINOMEscan | KINOMEscan |
| 20343 | Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values | Microscopy/Imaging |
| 20344 | Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10445-101-1 | MedChem Express | 10661 |
(Kd <100 nM)