Cediranib - Small Molecule (ID:10444-101)
| HMS LINCS ID: |
10444-101
|
| Name: | Cediranib |
| Alternative Names: | Recentin; AZD2171 |
| LINCS ID: | |
| PubChem CID: | 9933475 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 450.21 |
| InChi: | InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 |
| InChi Key: | XXJWYDDUDKYVKI-UHFFFAOYSA-N |
| SMILES: | CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, CSF1R, DDR1, DDR2, EPHA6, FGFR1, FGFR2, FGFR3, FLG, FLT1, FLT4, KDR, KIT, MAP4K5, PDGFRA, PDGFRB, RET, RIPK2, SLK, SRC, STK10, STK35, TKT | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL2, AXL, BLK, EGFR, EPHA7, EPHB6, ERBB3, ERN1, FGFR4, FRK, FYN, HCK, LCK, LYN, MAP3K19, MAP4K1, MET, PTK6, STK33, TEK, TIE1, TNIK, TYRO3, YES1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ACVR1, ACVR1B, AIM1, AKT1, AKT2, ALK, AURKA, AURKB, AURKC, BTK, CAMK1, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC7, CDK1, CDK2, CDK5, CDK7, CDK8, CDK9, CHEK1, CHEK2, CHUK, CLK2, CLK4, CSNK1A1, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DYRK1A, DYRK1B, DYRK3, DYRK4, EEF2K, EIF2AK1, EPHA1, EPHA2, EPHA3, EPHA8, EPHB4, ERBB2, ERBB4, FER, FES, FGR, GAK, GRK5, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, IKBKE, INSR, IRAK1, ITK, JAK2, JAK3, LIMK1, LTK, MAP2K1, MAP2K2, MAP2K5, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MATK, MELK, MERTK, MINK1, MST1, MST1R, NEK2, NEK4, NTRK1, NTRK2, NTRK3, PAK4, PDK1, PDPK1, PHKG2, PIM1, PIM2, PIM3, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCI, PRKCQ, PRKCZ, PRKD2, PRKD3, PRKG1, PRKG2, PRKX, PTK2, PTK2B, ROCK1, ROCK2, ROS1, RPS6KA3, RPS6KB1, SIK2, SRMS, SRPK1, STK17A, STK26, STK4, SYK, TAOK1, TAOK2, TAOK3, TBK1, TGFBR1, TNK2, TSSK1B, TSSK2 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20343 | Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values | Microscopy/Imaging |
| 20344 | Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10444-101-1 | MedChem Express | 10890 |
(Kd <100 nM)