Axitinib - Small Molecule (ID:10443-101)
| HMS LINCS ID: |
10443-101
|
| Name: | Axitinib |
| Alternative Names: | AG013736 |
| LINCS ID: | |
| PubChem CID: | 6450551 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 386.12 |
| InChi: | InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26) |
| InChi Key: | RITAVMQDGBJQJZ-UHFFFAOYSA-N |
| SMILES: | CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, ABL2, AIM1, AURKA, AURKB, AURKC, CSF1R, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB, PLK4, TIE1 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AXL, CDKL2, DDR1, EPHB6, FGFR1, FGFR2, FGFR3, FLG, FLT3, LRRK2, MAP2K5, MAP3K19, MAP4K1, MAP4K2, MAP4K4, MAP4K5, MINK1, RET, SLK, STK16, TEK, TNIK, TNK1, ULK3 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AAK1, ACVR1, ACVR2B, AKT1, AKT2, ALK, ANKK1, BLK, BMP2K, BMPR1B, BRSK1, BTK, CAMK1, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMKK1, CAMKK2, CDC42BPB, CDC7, CDK1, CDK16, CDK2, CDK5, CDK7, CDK8, CDK9, CHEK1, CHEK2, CHUK, CLK2, CLK4, CSK, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK2A1, CSNK2A2, DAPK3, DCLK1, DDR2, DYRK1A, DYRK1B, DYRK3, EEF2K, EIF2AK2, EPHA2, ERBB2, ERBB4, FGR, FYN, GAK, GRK4, GRK5, GSK3A, GSK3B, HIPK2, HIPK4, HUNK, IGF1R, IKBKB, IKBKE, INSR, IRAK1, ITK, JAK2, JAK3, LCK, LIMK1, LTK, LYN, MAP2K1, MAP2K2, MAP3K12, MAP3K3, MAP3K4, MAP3K9, MAP4K3, MAPK1, MAPK10, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MELK, MERTK, MET, MKNK2, MST1, MST1R, MYLK2, MYLK3, MYO3A, NEK2, NEK4, NTRK1, NTRK2, NTRK3, NUAK2, PAK4, PASK, PDK1, PDPK1, PHKG2, PIM1, PIM2, PKN2, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCQ, PRKCZ, PRKD3, PRKG1, PRKG2, PRKX, PTK2, PTK2B, RIOK1, RIOK3, RIPK1, RIPK2, RIPK4, ROCK1, ROCK2, ROS1, RPS6KA3, RPS6KB1, SIK1, SRC, SRPK1, SRPK3, STK10, STK3, STK4, TAOK1, TBK1, TESK1, TKT, TNK2, TSSK1B, TSSK2, TTK, TXK, TYK2, TYRO3, ULK2, YES1 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10443-101-1 | MedChem Express | 06766 |
(Kd <100 nM)