PP1 - Small Molecule (ID:10405-101)

HMS LINCS ID: 10405-101
Name: PP1
Alternative Names:
LINCS ID:
PubChem CID: 1400
ChEBI ID:
ChEMBL ID:
Molecular Mass: 281.16
InChi: InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChi Key: ZVPDNRVYHLRXLX-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
BLK, BTK, FRK, FYN, Lck, LYN, PTK6, RET, RIPK2, SRC
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, CLK4, CSF1R, CSK, CSNK1D, EGFR, EPHA2, ERBB2, ERBB4, FGFR1, FLG, FLT1, FLT4, KDR, KIT, LCK, LIMK1, NTRK2, NTRK3, RPS6KA3, RPS6KB1, SRC, SRMS
3
(equivalent to 1µM ≤ Kd < 10 µM)
AIM1, AKT1, AKT2, AKT3, ALK, AURKA, AURKB, AXL, CAMK1, CAMK2B, CAMK2D, CAMK2G, CDC42BPA, CDC7, CDK1, CDK2, CHEK1, CHEK2, CHUK, CLK2, CSNK1A1, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DYRK1A, DYRK3, DYRK4, EEF2K, FER, FES, FGFR3, FLT3, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, INSR, IRAK1, ITK, JAK2, JAK3, MAP4K2, MAP4K4, MAP4K5, MAPK1, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MATK, MELK, MET, MINK1, NEK4, NTRK1, PAK4, PDK1, PDPK1, PHKG2, PIM2, PIM3, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCZ, PRKD2, PRKD3, PRKG1, PRKG2, PRKX, PTK2, PTK2B, ROCK1, ROCK2, ROS1, RPS6KA5, SLK, SRPK1, STK17A, STK3, SYK, TAOK1, TEK, TSSK1B, TSSK2, TYK2, TYRO3
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10405-101-1 MedChem Express 09735