PP1 - Small Molecule (ID:10405-101)
HMS LINCS ID: | 10405-101 |
Name: | PP1 |
Alternative Names: | |
LINCS ID: | |
PubChem CID: | 1400 |
ChEBI ID: | |
ChEMBL ID: | |
Molecular Mass: | 281.16 |
InChi: | InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) |
InChi Key: | ZVPDNRVYHLRXLX-UHFFFAOYSA-N |
SMILES: | CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
BLK, BTK, FRK, FYN, Lck, LYN, PTK6, RET, RIPK2, SRC | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, CLK4, CSF1R, CSK, CSNK1D, EGFR, EPHA2, ERBB2, ERBB4, FGFR1, FLG, FLT1, FLT4, KDR, KIT, LCK, LIMK1, NTRK2, NTRK3, RPS6KA3, RPS6KB1, SRC, SRMS |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AIM1, AKT1, AKT2, AKT3, ALK, AURKA, AURKB, AXL, CAMK1, CAMK2B, CAMK2D, CAMK2G, CDC42BPA, CDC7, CDK1, CDK2, CHEK1, CHEK2, CHUK, CLK2, CSNK1A1, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DYRK1A, DYRK3, DYRK4, EEF2K, FER, FES, FGFR3, FLT3, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, INSR, IRAK1, ITK, JAK2, JAK3, MAP4K2, MAP4K4, MAP4K5, MAPK1, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MATK, MELK, MET, MINK1, NEK4, NTRK1, PAK4, PDK1, PDPK1, PHKG2, PIM2, PIM3, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCZ, PRKD2, PRKD3, PRKG1, PRKG2, PRKX, PTK2, PTK2B, ROCK1, ROCK2, ROS1, RPS6KA5, SLK, SRPK1, STK17A, STK3, SYK, TAOK1, TEK, TSSK1B, TSSK2, TYK2, TYRO3 |
10 (confirmed non-binding) |
Batch Information for HMSL10405-101-1:
HMS LINCS Batch ID: | 10405-101-1 |
Provider: | MedChem Express |
Provider Batch ID: | 09735 |
Salt: | 101 |
Molecular Formula: | C16H19N5 |
Molecular Weight: | 281.36 |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2015-08-27 |
Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10405-101-1:
Date | HMS QC Outcome | Comment | Files |
---|---|---|---|
08/31/2015 | PASS | HMSL10405-101-1_LCMS.pdf |
(Kd <100 nM)