PP1 - Small Molecule (ID:10405-101)
| HMS LINCS ID: |
10405-101
|
| Name: | PP1 |
| Alternative Names: | |
| LINCS ID: | |
| PubChem CID: | 1400 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 281.16 |
| InChi: | InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) |
| InChi Key: | ZVPDNRVYHLRXLX-UHFFFAOYSA-N |
| SMILES: | CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
BLK, BTK, FRK, FYN, Lck, LYN, PTK6, RET, RIPK2, SRC | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, CLK4, CSF1R, CSK, CSNK1D, EGFR, EPHA2, ERBB2, ERBB4, FGFR1, FLG, FLT1, FLT4, KDR, KIT, LCK, LIMK1, NTRK2, NTRK3, RPS6KA3, RPS6KB1, SRC, SRMS |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AIM1, AKT1, AKT2, AKT3, ALK, AURKA, AURKB, AXL, CAMK1, CAMK2B, CAMK2D, CAMK2G, CDC42BPA, CDC7, CDK1, CDK2, CHEK1, CHEK2, CHUK, CLK2, CSNK1A1, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DYRK1A, DYRK3, DYRK4, EEF2K, FER, FES, FGFR3, FLT3, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, INSR, IRAK1, ITK, JAK2, JAK3, MAP4K2, MAP4K4, MAP4K5, MAPK1, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MATK, MELK, MET, MINK1, NEK4, NTRK1, PAK4, PDK1, PDPK1, PHKG2, PIM2, PIM3, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCZ, PRKD2, PRKD3, PRKG1, PRKG2, PRKX, PTK2, PTK2B, ROCK1, ROCK2, ROS1, RPS6KA5, SLK, SRPK1, STK17A, STK3, SYK, TAOK1, TEK, TSSK1B, TSSK2, TYK2, TYRO3 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10405-101-1 | MedChem Express | 09735 |
(Kd <100 nM)