Poziotinib - Small Molecule (ID:10397-101)
| HMS LINCS ID: |
10397-101
|
| Name: | Poziotinib |
| Alternative Names: | HM781-36B; NOV120101 |
| LINCS ID: | |
| PubChem CID: | 25127713 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 490.10 |
| InChi: | InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29) |
| InChi Key: | LPFWVDIFUFFKJU-UHFFFAOYSA-N |
| SMILES: | COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
EGFR, ERBB2, ERBB4 |
Batch Information for HMSL10397-101-1:
| HMS LINCS Batch ID: | 10397-101-1 |
| Provider: | MedChem Express |
| Provider Batch ID: | 15405 |
| Salt: | 101 |
| Molecular Formula: | C23H21Cl2FN4O3 |
| Molecular Weight: | 491.34 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-08-27 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10397-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 08/31/2015 | PASS | HMSL10397-101-1_LCMS.pdf |
(equivalent to 100 nM ≤ Kd < 1µM)