Pacritinib - Small Molecule (ID:10381-101)
| HMS LINCS ID: |
10381-101
|
| Name: | Pacritinib |
| Alternative Names: | SB1518 |
| LINCS ID: | |
| PubChem CID: | 46216796 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 472.25 |
| InChi: | InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31) |
| InChi Key: | HWXVIOGONBBTBY-UHFFFAOYSA-N |
| SMILES: | C1CCN(C1)CCOC2=C3COCC=CCOCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
FLT3, JAK2, TYK2 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | JAK3 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | CCNA1, CCNA2, CDK2, JAK1 |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10381-101-1 | MedChem Express | 12003 |
(Kd <100 nM)