Filgotinib - Small Molecule (ID:10373-101)
| HMS LINCS ID: |
10373-101
|
| Name: | Filgotinib |
| Alternative Names: | GLPG0634 |
| LINCS ID: | |
| PubChem CID: | 49831257 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 425.15 |
| InChi: | InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27) |
| InChi Key: | RIJLVEAXPNLDTC-UHFFFAOYSA-N |
| SMILES: | C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
Jak1, JAK1 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | CSF1R, FLT3, FLT4, JAK3, TYK2 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | JAK2 |
10 (confirmed non-binding) |
Batch Information for HMSL10373-101-1:
| HMS LINCS Batch ID: | 10373-101-1 |
| Provider: | MedChem Express |
| Provider Batch ID: | 11067 |
| Salt: | 101 |
| Molecular Formula: | C21H23N5O3S |
| Molecular Weight: | 425.5 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-08-27 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10373-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 08/31/2015 | PASS | HMSL10373-101-1_LCMS.pdf |
(Kd <100 nM)