Navitoclax - Small Molecule (ID:10367-101)

HMS LINCS ID: 10367-101
Name: Navitoclax
Alternative Names: ABT 263; ABT-263; ABT263
LINCS ID: LSM-42776
PubChem CID: 24978538
ChEBI ID:
ChEMBL ID:
Molecular Mass: 973.30
InChi: InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1
InChi Key: JLYAXFNOILIKPP-KXQOOQHDSA-N
SMILES: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2017-05-09

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
BAD, BCL2, BCL2L1
2
(equivalent to 100 nM ≤ Kd < 1µM)
BCL2L2
10
(confirmed non-binding)

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20232
Live-cell imaging of cell-to-cell variability in caspase-8 FRET reporter activity and cell fate trajectory modeling
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10367-101-1 Selleck Chemicals