Navitoclax - Small Molecule (ID:10367-101)
| HMS LINCS ID: |
10367-101
|
| Name: | Navitoclax |
| Alternative Names: | ABT 263; ABT-263; ABT263 |
| LINCS ID: | LSM-42776 |
| PubChem CID: | 24978538 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 973.30 |
| InChi: | InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1 |
| InChi Key: | JLYAXFNOILIKPP-KXQOOQHDSA-N |
| SMILES: | CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2017-05-09 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
BAD, BCL2, BCL2L1 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | BCL2L2 |
10 (confirmed non-binding) |
Batch Information for HMSL10367-101-1:
| HMS LINCS Batch ID: | 10367-101-1 |
| Provider: | Selleck Chemicals |
| Provider Batch ID: | |
| Salt: | 101 |
| Molecular Formula: | C47H55ClF3N5O6S3 |
| Molecular Weight: | 974.61 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-06-04 |
| Most Recent Update: | 2016-12-02 |
(Kd <100 nM)