JNK-IN-8 - Small Molecule (ID:10363-101)
| HMS LINCS ID: |
10363-101
|
| Name: | JNK-IN-8 |
| Alternative Names: | JNK Inhibitor XVI |
| LINCS ID: | LSM-44525 |
| PubChem CID: | 76516568 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 507.24 |
| InChi: | InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35) |
| InChi Key: | GJFCSAPFHAXMSF-UHFFFAOYSA-N |
| SMILES: | CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)C=CCN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2018-03-30 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
MAPK8, MAPK9 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | MAPK10, PRKX |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20212 | JNK-IN-8 KINOMEscan | KINOMEscan |
| 20213 | JNK-IN-8 KiNativ -- single dose experiment | KiNativ |
| 20219 | Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging | Microscopy/Imaging |
| 20233 | Synovial Fibroblast 1: Secretion response of primary human synovial fibroblast samples from one healthy and one rheumatoid arthritis donor to a panel of 10 stimuli and 10 small molecule inhibitors | Bead-based immunoassay |
| 20234 | Synovial Fibroblast 3.1: Secretion response of seven primary human synovial fibroblast samples from healthy and rheumatoid arthritis donors to a panel of 3 stimuli and 5 small molecule inhibitors (replicate 1 of 2) | Bead-based immunoassay |
| 20235 | Synovial Fibroblast 3.2: Secretion response of seven primary human synovial fibroblast samples from healthy and rheumatoid arthritis-diagnosed donors to a panel of 3 stimuli and 5 small molecule inhibitors (replicate 2 of 2) | Bead-based immunoassay |
| 20272 | Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) | Microscopy/Imaging |
| 20273 | Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) | Microscopy/Imaging |
| 20274 | Phosphorylation state and protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (immunofluorescence dataset 1 of 4) | Microscopy/Imaging |
| 20275 | Phosphorylation state and protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (immunofluorescence dataset 2 of 4) | Microscopy/Imaging |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10363-101-1 | EMD Millipore | |
| 10363-101-2 | Nathanael Gray (DFCI) |
(Kd <100 nM)