Valproic acid - Small Molecule (ID:10346-110)
| HMS LINCS ID: |
10346-110
|
| Name: | Valproic acid |
| Alternative Names: | Depakine |
| LINCS ID: | LSM-4620 |
| PubChem CID: | 3549980 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 144.12 |
| InChi: | InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10) |
| InChi Key: | NIJJYAXOARWZEE-UHFFFAOYSA-N |
| SMILES: | CCCC(CCC)C(=O)O |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2018-03-30 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABAT, GSK3A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8 | |
3 (equivalent to 1µM ≤ Kd < 10 µM) | TDP1 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20120 | Metrics other than potency reveal systematic variation in responses to cancer drugs | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10346-110-1 | Enzo Life Sciences |
(equivalent to 100 nM ≤ Kd < 1µM)