Rocilinostat - Small Molecule (ID:10315-101)
| HMS LINCS ID: |
10315-101
|
| Name: | Rocilinostat |
| Alternative Names: | ACY-1215 |
| LINCS ID: | LSM-6324 |
| PubChem CID: | 53340666 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 433.21 |
| InChi: | InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30) |
| InChi Key: | QGZYDVAGYRLSKP-UHFFFAOYSA-N |
| SMILES: | C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
HDAC1, HDAC2, HDAC3, HDAC6 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | HDAC8 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | HDAC4, HDAC5, HDAC7 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20276 | Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) | Microscopy/Imaging |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10315-101-1 | Haoyuan chemexpress | HY-16026-20130410 |
(Kd <100 nM)