Pracinostat - Small Molecule (ID:10313-101)
| HMS LINCS ID: |
10313-101
|
| Name: | Pracinostat |
| Alternative Names: | SB939 |
| LINCS ID: | LSM-43290 |
| PubChem CID: | 56603532 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 358.24 |
| InChi: | InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25) |
| InChi Key: | JHDKZFFAIZKUCU-UHFFFAOYSA-N |
| SMILES: | CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2018-03-30 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC8, HDAC9 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | HDAC6, HDAC7 |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20276 | Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) | Microscopy/Imaging |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10313-101-1 | Haoyuan chemexpress | HY-13322-20111215 |
(Kd <100 nM)