Mocetinostat - Small Molecule (ID:10312-101)

HMS LINCS ID: 10312-101
Name: Mocetinostat
Alternative Names: MGCD0103
LINCS ID: LSM-5344
PubChem CID: 9865515
ChEBI ID:
ChEMBL ID:
Molecular Mass: 396.17
InChi: InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29)
InChi Key: HRNLUBSXIHFDHP-UHFFFAOYSA-N
SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
NCOR1, NCOR2
2
(equivalent to 100 nM ≤ Kd < 1µM)
HDAC1, HDAC11, HDAC2, HDAC3
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20276
Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4)
 Microscopy/Imaging

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10312-101-1 Haoyuan chemexpress HY-12164-20111223