Dinaciclib - Small Molecule (ID:10287-101)

HMS LINCS ID: 10287-101
Name: Dinaciclib
Alternative Names: SCH727965
LINCS ID: LSM-6306
PubChem CID: 46926350
ChEBI ID:
ChEMBL ID:
Molecular Mass: 396.23
InChi: InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1
InChi Key: PIMQWRZWLQKKBJ-SFHVURJKSA-N
SMILES: CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
2
(equivalent to 100 nM ≤ Kd < 1µM)
CDK1, CDK14, CDK2, CDK5, CDK9
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20128
Dinaciclib KINOMEscan
 KINOMEscan
20343
Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values
 Microscopy/Imaging
20344
Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics
 Analysis

KINOMEscan Image

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10287-101-1 Selleck Chemicals
10287-101-2 MedChem Express 14760