PHA-767491 - Small Molecule (ID:10285-101)

HMS LINCS ID: 10285-101
Name: PHA-767491
Alternative Names:
LINCS ID: LSM-6304
PubChem CID: 11715767
ChEBI ID:
ChEMBL ID:
Molecular Mass: 213.09
InChi: InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
InChi Key: DKXHSOUZPMHNIZ-UHFFFAOYSA-N
SMILES: C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
CDC7, CDK8, CDK9, CLK4, CSNK1A1, CSNK1D, CSNK1G2, DAPK3, DYRK1A, DYRK1B, DYRK3, GSK3A, IRAK1, MAPK12, MAPK13, PKN2, PRKCQ, PRKG1, PRKG2, ROCK2, STK17A
2
(equivalent to 100 nM ≤ Kd < 1µM)
CDK1, CDK2, CDK5, CHUK, CIT, CLK1, CLK2, CSNK1E, CSNK1G1, CSNK1G3, DYRK4, GSK3B, HIPK2, HIPK4, JAK2, JAK3, LRRK2, MAP3K19, MAPK15, MAPKAPK2, MAPKAPK5, MINK1, MKNK2, PASK, PBK, PIM2, PKD2, PLK3, PLK4, PRKCD, PRKCE, PRKD2, PRKD3, PRKX, ROCK1, TPTEP2-CSNK1E
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ACVR1, AIM1, AKT1, AKT2, ALK, AURKA, AURKB, AXL, BLK, BRSK1, BTK, CAMK1, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42BPA, CDK7, CHEK1, CHEK2, CSF1R, CSNK2A1, EEF2K, EGFR, EPHA2, ERBB2, ERBB4, FER, FES, FGFR1, FGFR3, FLG, FLT1, FLT3, FLT4, FRK, FYN, GRK5, IGF1R, IKBKE, INSR, IRAK4, ITK, KDR, KIT, LCK, LIMK1, LTK, LYN, MAP2K1, MAP2K2, MAP4K2, MAP4K4, MAP4K5, MAPK1, MAPK14, MAPK8, MAPK9, MARK2, MARK3, MATK, MELK, MET, MKNK1, MST1R, NEK2, NEK4, NTRK1, NTRK2, NTRK3, PAK4, PDGFRA, PDGFRB, PDK1, PDPK1, PHKG2, PIM1, PIM3, PLK1, PRKAA1, PRKACA, PRKCG, PRKCI, PRKCZ, PTK2, PTK2B, PTK6, RET, ROS1, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, SGK2, SLK, SRC, SRMS, SRPK1, STK3, SYK, TAOK1, TBK1, TNK2, TSSK1B, TSSK2, TYK2, TYRO3
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20126
PHA-767491 KINOMEscan
 KINOMEscan

KINOMEscan Image

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10285-101-1 Selleck Chemicals