Dabrafenib - Small Molecule (ID:10284-101)

HMS LINCS ID: 10284-101
Name: Dabrafenib
Alternative Names: GSK2118436
LINCS ID: LSM-6303
PubChem CID: 44462760
ChEBI ID:
ChEMBL ID:
Molecular Mass: 519.10
InChi: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
InChi Key: BFSMGDJOXZAERB-UHFFFAOYSA-N
SMILES: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ARAF, BRAF
2
(equivalent to 100 nM ≤ Kd < 1µM)
BMPR1B, CDK16, CDK17, CDK18, COQ8A, COQ8B, CSK, LIMK2, PF3D7_0217500, PIK3C2B, PLK4, RAF1, SRMS, TESK1, TGFBR1
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20131
Dabrafenib KINOMEscan
 KINOMEscan

KINOMEscan Image

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10284-101-1 Haoyuan chemexpress HY-14660-20120629