Topotecan - Small Molecule (ID:10278-999)
| HMS LINCS ID: |
10278-999
|
| Name: | Topotecan |
| Alternative Names: | Hycamtin |
| LINCS ID: | LSM-5662 |
| PubChem CID: | 60700 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 421.16 |
| InChi: | InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1 |
| InChi Key: | UCFGDBYHRUNTLO-QHCPKHFHSA-N |
| SMILES: | CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-05-06 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
HIF1A | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | TOP1 |
10 (confirmed non-binding) |
Batch Information for HMSL10278-999-1:
| HMS LINCS Batch ID: | 10278-999-1 |
| Provider: | J Park (UCSF) |
| Provider Batch ID: | |
| Salt: | 999 |
| Molecular Formula: | |
| Molecular Weight: | |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2012-11-14 |
| Most Recent Update: | 2016-12-02 |
(Kd <100 nM)