Nutlin 3a - Small Molecule (ID:10268-101)

HMS LINCS ID: 10268-101
Name: Nutlin 3a
Alternative Names:
LINCS ID: LSM-6351
PubChem CID: 11433190
ChEBI ID:
ChEMBL ID:
Molecular Mass: 580.16
InChi: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
InChi Key: BDUHCSBCVGXTJM-WUFINQPMSA-N
SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
Mdm2, MDM2, MDM2
2
(equivalent to 100 nM ≤ Kd < 1µM)
TP53
3
(equivalent to 1µM ≤ Kd < 10 µM)
MDM4

Batch Information for HMSL10268-101-1:

HMS LINCS Batch ID: 10268-101-1
Provider: Roche
Provider Batch ID:
Salt: 101
Molecular Formula:
Molecular Weight:
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2012-11-14
Most Recent Update: 2016-12-02