NSC 663284 - Small Molecule (ID:10266-101)
| HMS LINCS ID: |
10266-101
|
| Name: | NSC 663284 |
| Alternative Names: | |
| LINCS ID: | LSM-2042 |
| PubChem CID: | 379077 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 321.09 |
| InChi: | InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2 |
| InChi Key: | BMKPVDQDJQWBPD-UHFFFAOYSA-N |
| SMILES: | C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
CDC25A, CDC25B, CDC25C, KMT5A | |
3 (equivalent to 1µM ≤ Kd < 10 µM) | DUSP3 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20120 | Metrics other than potency reveal systematic variation in responses to cancer drugs | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10266-101-1 | Tocris |
(equivalent to 100 nM ≤ Kd < 1µM)