Pevonedistat - Small Molecule (ID:10265-102)

HMS LINCS ID: 10265-102
Name: Pevonedistat
Alternative Names: MLN 4924; MLN-4924; MLN4924
LINCS ID: LSM-6263
PubChem CID: 16720766
ChEBI ID:
ChEMBL ID: 1231160
Molecular Mass: 443.16
InChi: InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1
InChi Key: MPUQHZXIXSTTDU-QXGSTGNESA-N
SMILES: C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-08-09

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
2
(equivalent to 100 nM ≤ Kd < 1µM)
UBA3

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20350
Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 1 of 2: Normalized growth rate inhibition values.
Microscopy/Imaging
20351
Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10265-102-2 MedChem Express 09546