ICRF-193 - Small Molecule (ID:10259-101)
| HMS LINCS ID: |
10259-101
|
| Name: | ICRF-193 |
| Alternative Names: | |
| LINCS ID: | LSM-4280 |
| PubChem CID: | 115150 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 282.13 |
| InChi: | InChI=1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20) |
| InChi Key: | OBYGAPWKTPDTAS-UHFFFAOYSA-N |
| SMILES: | CC(C(C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
MAPT, TOP2A, TOP2B | |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10259-101-1 | Sigma-Aldrich |
(equivalent to 100 nM ≤ Kd < 1µM)