Bortezomib - Small Molecule (ID:10241-101)
| HMS LINCS ID: |
10241-101
|
| Name: | Bortezomib |
| Alternative Names: | Velcade |
| LINCS ID: | LSM-6281 |
| PubChem CID: | 387447 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 384.20 |
| InChi: | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 |
| InChi Key: | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| SMILES: | B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
NFKB1, NFKB2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, RELA | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | CTRB1, CTSG, PSMB2 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | CMA1, CTSA, ELANE |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20120 | Metrics other than potency reveal systematic variation in responses to cancer drugs | Analysis |
| 20232 | Live-cell imaging of cell-to-cell variability in caspase-8 FRET reporter activity and cell fate trajectory modeling | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10241-101-1 | LC Laboratories | |
| 10241-101-2 | Santa Cruz Biotechnology | |
| 10241-101-3 | MedChem Express | 10264 |
| 10241-101-4 | LC Laboratories |
(Kd <100 nM)