Bortezomib - Small Molecule (ID:10241-101)
| HMS LINCS ID: |
10241-101
|
| Name: | Bortezomib |
| Alternative Names: | Velcade |
| LINCS ID: | LSM-6281 |
| PubChem CID: | 387447 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 384.20 |
| InChi: | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 |
| InChi Key: | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| SMILES: | B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
NFKB1, NFKB2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, RELA | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | CTRB1, CTSG, PSMB2 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | CMA1, CTSA, ELANE |
10 (confirmed non-binding) |
Batch Information for HMSL10241-101-1:
| HMS LINCS Batch ID: | 10241-101-1 |
| Provider: | LC Laboratories |
| Provider Batch ID: | |
| Salt: | 101 |
| Molecular Formula: | C19H25BN4O4 |
| Molecular Weight: | 384.24 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2012-11-14 |
| Most Recent Update: | 2016-12-02 |
(Kd <100 nM)