AS-252424 - Small Molecule (ID:10240-101)
| HMS LINCS ID: |
10240-101
|
| Name: | AS-252424 |
| Alternative Names: | |
| LINCS ID: | LSM-4263 |
| PubChem CID: | 56965900 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 305.02 |
| InChi: | InChI=1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19) |
| InChi Key: | OYYVWNDMOQPMGE-UHFFFAOYSA-N |
| SMILES: | C1=CC(=C(C=C1F)O)C2=CC=C(O2)C=C3C(=O)NC(=O)S3 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
CSNK2A1, CSNK2A2, CSNK2B, PIK3CG | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | PIK3CA |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
| 20341 | AS-252424 KINOMEscan | KINOMEscan |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10240-101-1 | Sigma-Aldrich | |
| 10240-101-2 | Nathanael Gray (DFCI) |
(Kd <100 nM)