AG1478 - Small Molecule (ID:10223-101)
| HMS LINCS ID: |
10223-101
|
| Name: | AG1478 |
| Alternative Names: | Tyrphostin |
| LINCS ID: | LSM-1224 |
| PubChem CID: | 2051 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 315.08 |
| InChi: | InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) |
| InChi Key: | GFNNBHLJANVSQV-UHFFFAOYSA-N |
| SMILES: | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
EGFR | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, ABL2, GAK, MAPK14, MKNK1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | FBP1, SRC |
10 (confirmed non-binding) |
Batch Information for HMSL10223-101-1:
| HMS LINCS Batch ID: | 10223-101-1 |
| Provider: | Santa Cruz Biotechnology |
| Provider Batch ID: | B2312 |
| Salt: | 101 |
| Molecular Formula: | C16H14ClN3O2 |
| Molecular Weight: | 315.75 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2011-07-15 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10223-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 04/13/2015 | PASS | HMSL10223-101-1_LCMS.pdf |
(Kd <100 nM)