PKC412 - Small Molecule (ID:10220-999)
| HMS LINCS ID: |
10220-999
|
| Name: | PKC412 |
| Alternative Names: | |
| LINCS ID: | LSM-1221 |
| PubChem CID: | 16760627 |
| ChEBI ID: | |
| ChEMBL ID: | 338448 |
| Molecular Mass: | 570.23 |
| InChi: | InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40) |
| InChi Key: | BMGQWWVMWDBQGC-UHFFFAOYSA-N |
| SMILES: | CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-07-12 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
AAK1, AIM1, AURKB, CAMK2A, CAMK2D, CAMKK2, EIF2AK4, FLT3, GRK1, GRK7, JAK2, JAK3, KIT, MAP3K11, MAP3K19, MAP3K9, MARK3, MST1, NUAK1, NUAK2, PKN1, PKN2, PLK4, PRKCB, PRKCG, PRKCZ, PRKG2, PRPF4, PRPF4B, RET, RIOK2, SIK3, SRPK1, SRPK3, STK4, SYK, TBK1, TNK1 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AKT1, AKT2, ALK, AURKA, AURKC, AXL, BLK, BMP2K, BRSK2, CAMK1D, CAMK2B, CAMK2G, CAMKK1, CLK1, CLK2, CLK4, CSF1R, CSNK2A1, DAPK2, DYRK1A, DYRK1B, FGR, FLT1, FLT4, GAK, GRK4, HCK, HIPK4, HUNK, IKBKE, IRAK3, JAK1, KDR, LCK, LRRK2, MAP3K10, MAP3K2, MAP3K3, MAP3K7, MAP4K3, MAP4K4, MARK1, MARK2, MARK4, MAST1, MELK, MET, MINK1, MKNK2, MYLK4, NTRK1, NTRK2, PAK3, PDGFRA, PDGFRB, PDK1, PDPK1, PF3D7_0217500, PHKG1, PIK3C2G, PIM1, PIM3, PIP4K2B, PIP5K1A, PRKAA1, PRKAA2, PRKACA, PRKACB, PRKCA, PRKCD, PRKCE, PRKCH, PRKCQ, PRKG1, PRKX, PTK2B, RIOK3, ROS1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, SIK1, SIK1B, SIK2, SLK, SRPK2, STK10, STK11, STK16, STK3, STK33, TNK2, TNKS2, TTK, TYK2, YES1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ABL1, AKT3, BRSK1, C8orf44-SGK3, CAMK1, CAMK1G, CDK19, CHEK1, CHUK, CLK3, CSK, DAPK1, DAPK3, DDR1, DMPK, DSTYK, EGFR, EIF2AK2, EPHB6, ERBB4, ERN1, FER, FGFR1, FGFR2, FGFR3, FLG, FRK, FYN, GSK3A, GSK3B, HIPK2, HIPK3, ICK, IKBKB, LATS1, LATS2, LTK, LYN, MAP2K3, MAP2K4, MAP2K6, MAP3K13, MAP4K1, MAP4K2, MAP4K5, MAPK10, MAPK8, MAPK9, MERTK, MYLK, MYLK3, NTRK3, PAK1, PAK2, PHKG2, PIK3C2B, PIK3CA, PIM2, PKD2, PRKACG, PRKCI, PRKD2, PRKD3, RIOK1, ROCK1, ROCK2, RPS6KA6, RPS6KB1, SGK3, SRC, STK17A, STK17B, STK25, STK32A, TEK, TIE1, TNIK, TSSK1B, Tuba1a, ULK3, WEE1, ZAP70 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20187 | PKC-412 KINOMEscan | KINOMEscan |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10220-999-2 |
(Kd <100 nM)