U-0126 - Small Molecule (ID:10219-101)
HMS LINCS ID: | 10219-101 |
Name: | U-0126 |
Alternative Names: | |
LINCS ID: | LSM-42806 |
PubChem CID: | 5637 |
ChEBI ID: | |
ChEMBL ID: | 34704 |
Molecular Mass: | 380.09 |
InChi: | InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2 |
InChi Key: | DVEXZJFMOKTQEZ-UHFFFAOYSA-N |
SMILES: | C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2018-03-30 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
MAP2K2 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | MAP2K1, MAP2K1 |
10 (confirmed non-binding) |
Datasets:
HMS Dataset ID | Dataset Title | HMS Dataset Type |
---|---|---|
20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
Batch Information:
HMS LINCS Batch ID | Provider | Provider Batch ID |
---|---|---|
10219-101-1 | AG Scientific | A8321 |
10219-101-2 | LC Laboratories |
(Kd <100 nM)