RAF 265 - Small Molecule (ID:10206-101)

HMS LINCS ID: 10206-101
Name: RAF 265
Alternative Names: CHIR-265
LINCS ID: LSM-1207
PubChem CID: 11656518
ChEBI ID:
ChEMBL ID:
Molecular Mass: 518.13
InChi: InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
InChi Key: YABJJWZLRMPFSI-UHFFFAOYSA-N
SMILES: CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
CIT, DDR1, EIF2AK4, EPHB6, MAP3K19, MAP3K20, STK10
2
(equivalent to 100 nM ≤ Kd < 1µM)
BRAF, CSF1R, DDR2, EIF2AK2, FLT1, FRK, HIPK4, KDR, KIT, LCK, LYN, MAP3K7, MAP4K5, PDGFRB, RAF1, RET, RIPK2, SLK, TAOK2, TAOK3, TIE1, TKT, TYK2, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ABL2, BLK, CDK19, EPHA1, EPHA2, EPHA4, EPHA6, EPHA8, FER, FGFR1, FLG, FLT3, FLT4, FPGT-TNNI3K, FYN, HCK, MAP2K5, MAP3K11, MAP4K2, MAP4K3, MAP4K4, MET, NEK5, PAK3, PDGFRA, PRKAA1, PTK6, RIPK1, SRC, STK25, STK36, SYK, TAOK1, TEK, TNIK, TNK1, TNNI3K
10
(confirmed non-binding)
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Batch Information for HMSL10206-101-3:

HMS LINCS Batch ID: 10206-101-3
Provider: MedChem Express
Provider Batch ID: 13082
Salt: 101
Molecular Formula: C24H16F6N6O
Molecular Weight: 518.41
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-06-17
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10206-101-3:

Date HMS QC Outcome Comment Files
08/31/2015 PASS HMSL10206-101-3_LCMS.pdf