Cabozantinib - Small Molecule (ID:10194-106)
| HMS LINCS ID: |
10194-106
|
| Name: | Cabozantinib |
| Alternative Names: | XL-184; BMS-907351 |
| LINCS ID: | LSM-1195 |
| PubChem CID: | 25102847 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 501.17 |
| InChi: | InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34) |
| InChi Key: | ONIQOQHATWINJY-UHFFFAOYSA-N |
| SMILES: | COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
KDR, KIT, MET, RET | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AXL, FLT1, FLT3, FLT4, MERTK, NTRK2, ROS1, TEK, TYRO3 |
Batch Information for HMSL10194-106-1:
| HMS LINCS Batch ID: | 10194-106-1 |
| Provider: | Haoyuan chemexpress |
| Provider Batch ID: | HY-12044-20110919 |
| Salt: | 106 |
| Molecular Formula: | C32H30FN3O10 |
| Molecular Weight: | 635.59 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2011-07-15 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10194-106-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 04/13/2015 | PASS | HMSL10194-106-1_LCMS.pdf | |
| 11/14/2011 | PASS | None |
(Kd <100 nM)