Ki20227 - Small Molecule (ID:10187-101)
| HMS LINCS ID: |
10187-101
|
| Name: | Ki20227 |
| Alternative Names: | |
| LINCS ID: | LSM-1188 |
| PubChem CID: | 57345770 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 480.15 |
| InChi: | InChI=1S/C24H24N4O5S/c1-14(23-12-25-13-34-23)27-24(29)28-17-6-5-15(9-20(17)30-2)33-19-7-8-26-18-11-22(32-4)21(31-3)10-16(18)19/h5-14H,1-4H3,(H2,27,28,29) |
| InChi Key: | ZATITKHAYUKSBY-UHFFFAOYSA-N |
| SMILES: | CC(C1=CN=CS1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)OC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
CSF1R, DDR1, DDR2, EPHB6, KDR, KIT, MAP2K5, PDGFRA, PDGFRB, PTK6, SLK, STK10 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, ABL2, AURKB, AURKC, AXL, BLK, CSNK1E, FLT1, FLT4, FRK, HCK, LCK, LIMK2, LYN, MERTK, MET, PLK4, RIPK2, SRMS, TGFBR2, TNK2, TPTEP2-CSNK1E |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AURKA, BMPR1B, BTK, CSK, EGFR, EPHA1, EPHA8, ERBB4, FGR, FLT3, FYN, GAK, HIPK4, IRAK3, MAP2K1, MAP2K2, MAP3K19, MAP3K20, MAP4K5, MINK1, MST1R, NEK11, NLK, PF3D7_0217500, RET, SRC, STK4, TESK1, TNIK, TYRO3, YES1 |
Batch Information for HMSL10187-101-1:
| HMS LINCS Batch ID: | 10187-101-1 |
| Provider: | Haoyuan chemexpress |
| Provider Batch ID: | HY-10408_1-20110628 |
| Salt: | 101 |
| Molecular Formula: | C24H24N4O5S |
| Molecular Weight: | 480.54 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2011-07-15 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10187-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 04/13/2015 | PASS | HMSL10187-101-1_LCMS.pdf | |
| 11/14/2011 | PASS | None |
(Kd <100 nM)