GDC-0879 - Small Molecule (ID:10181-999)

HMS LINCS ID: 10181-999
Name: GDC-0879
Alternative Names:
LINCS ID: LSM-42801
PubChem CID: 57519545
ChEBI ID:
ChEMBL ID:
Molecular Mass: 334.14
InChi: InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2
InChi Key: DEZZLWQELQORIU-UHFFFAOYSA-N
SMILES: C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
BRAF, RAF1
2
(equivalent to 100 nM ≤ Kd < 1µM)
CSNK1E, MAP3K19, TPTEP2-CSNK1E
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ACVR1B, BMPR1B, CIT, CSNK1D, ERBB3, JAK1, MAP2K5, MAP4K4, MAPK10, MAPK3, MINK1, RIOK2, RIPK2, SLK, STK10, TGFBR1, TNIK
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20181
GDC-0879 KINOMEscan
 KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10181-999-2