Brivanib - Small Molecule (ID:10177-101)

HMS LINCS ID: 10177-101
Name: Brivanib
Alternative Names: BMS-540215
LINCS ID: LSM-1178
PubChem CID: 11451527
ChEBI ID:
ChEMBL ID:
Molecular Mass: 370.14
InChi: InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3
InChi Key: WCWUXEGQKLTGDX-UHFFFAOYSA-N
SMILES: CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OCC(C)O)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
FGFR1, FLG, FLT1, FLT4, Kdr, KDR, KIT, PDGFRA, PDGFRB, STK35
2
(equivalent to 100 nM ≤ Kd < 1µM)
DDR1, EPHA6, FGFR2, FGFR3, FGFR4, MAP3K19, MAP4K4, MINK1, RET, SLK, STK10, TEK, TNIK
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ABL2, BLK, CSF1R, EGFR, EPHA7, EPHB6, HCK, LCK, MAP2K5, MAP4K5, RIPK2, SRC, STK32B, STK33, TIE1
10
(confirmed non-binding)
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Batch Information for HMSL10177-101-1:

HMS LINCS Batch ID: 10177-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HY-10337_1-20100111
Salt: 101
Molecular Formula: C19H19FN4O3
Molecular Weight: 370.38
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10177-101-1:

Date HMS QC Outcome Comment Files
04/13/2015 PASS HMSL10177-101-1_LCMS.pdf
11/14/2011 PASS None