Brivanib - Small Molecule (ID:10177-101)
HMS LINCS ID: | 10177-101 |
Name: | Brivanib |
Alternative Names: | BMS-540215 |
LINCS ID: | LSM-1178 |
PubChem CID: | 11451527 |
ChEBI ID: | |
ChEMBL ID: | |
Molecular Mass: | 370.14 |
InChi: | InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3 |
InChi Key: | WCWUXEGQKLTGDX-UHFFFAOYSA-N |
SMILES: | CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OCC(C)O)C |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
FGFR1, FLG, FLT1, FLT4, Kdr, KDR, KIT, PDGFRA, PDGFRB, STK35 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | DDR1, EPHA6, FGFR2, FGFR3, FGFR4, MAP3K19, MAP4K4, MINK1, RET, SLK, STK10, TEK, TNIK |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ABL1, ABL2, BLK, CSF1R, EGFR, EPHA7, EPHB6, HCK, LCK, MAP2K5, MAP4K5, RIPK2, SRC, STK32B, STK33, TIE1 |
10 (confirmed non-binding) |
Batch Information for HMSL10177-101-1:
HMS LINCS Batch ID: | 10177-101-1 |
Provider: | Haoyuan chemexpress |
Provider Batch ID: | HY-10337_1-20100111 |
Salt: | 101 |
Molecular Formula: | C19H19FN4O3 |
Molecular Weight: | 370.38 |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2011-07-15 |
Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10177-101-1:
Date | HMS QC Outcome | Comment | Files |
---|---|---|---|
04/13/2015 | PASS | HMSL10177-101-1_LCMS.pdf | |
11/14/2011 | PASS | None |
(Kd <100 nM)