Y-27632 - Small Molecule (ID:10176-101)

HMS LINCS ID: 10176-101
Name: Y-27632
Alternative Names:
LINCS ID: LSM-1177
PubChem CID: 5711
ChEBI ID:
ChEMBL ID:
Molecular Mass: 247.17
InChi: InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)
InChi Key: IYOZTVGMEWJPKR-UHFFFAOYSA-N
SMILES: CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
PRKCQ
2
(equivalent to 100 nM ≤ Kd < 1µM)
CLK4, LRRK2, MKNK1, PKN2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKCD, PRKX, ROCK1, ROCK2, RPS6KA1, RPS6KA5
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ACVR1, AIM1, AKT1, AKT2, ALK, AURKA, AURKB, AXL, BLK, BRSK1, BTK, CAMK1, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCL2, CDC42BPA, CDC7, CDK1, CDK2, CDK5, CDK7, CDK8, CDK9, CHEK1, CHEK2, CHUK, CLK2, CSF1R, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK2A1, DAPK3, DYRK1A, DYRK1B, DYRK3, EEF2K, EGFR, EPHA2, ERBB2, ERBB4, FGFR1, FGFR3, FLG, FLT1, FLT3, FLT4, FYN, GRK5, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, IKBKE, INSR, IRAK1, ITK, JAK2, JAK3, KDR, KIT, LCK, LIMK1, LTK, LYN, MAP2K1, MAP2K2, MAP4K2, MAP4K4, MAP4K5, MAPK1, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MELK, MET, MINK1, MST1R, NEK2, NEK4, NTRK1, NTRK2, NTRK3, PAK4, PASK, PDGFRA, PDGFRB, PDK1, PDPK1, PHKG2, PIM1, PIM2, PLK1, PLK3, PLK4, PRKACA, PRKACB, PRKACG, PRKCG, PRKCZ, PRKD3, PRKG1, PRKG2, PTK2, PTK2B, RET, RPS6KA3, RPS6KB1, SRC, SRPK1, STK3, TAOK1, TBK1, TNK2, TSSK1B, TSSK2, TYK2, TYRO3
10
(confirmed non-binding)
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Batch Information for HMSL10176-101-2:

HMS LINCS Batch ID: 10176-101-2
Provider:
Provider Batch ID:
Salt: 101
Molecular Formula:
Molecular Weight:
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-12-02