Sunitinib - Small Molecule (ID:10175-999)

HMS LINCS ID: 10175-999
Name: Sunitinib
Alternative Names: Sutent; SU11248
LINCS ID: LSM-42800
PubChem CID: 3086686
ChEBI ID:
ChEMBL ID: 535
Molecular Mass: 398.21
InChi: InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)
InChi Key: WINHZLLDWRZWRT-UHFFFAOYSA-N
SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AAK1, AXL, BLK, BMP2K, CAMK2A, CHEK2, CLK1, CLK2, CLK4, CSF1R, CSNK1A1, CSNK1D, CSNK1E, DAPK3, FLT1, FLT3, FLT4, GAK, HIPK1, HIPK2, HIPK3, IRAK1, IRAK4, ITK, JAK1, KDR, KIT, LRRK2, MAP2K5, MAP3K13, MAP3K19, MAP3K2, MAP3K7, MAP4K1, MAP4K2, MAP4K5, MERTK, MINK1, MST1, MYLK2, MYLK3, MYLK4, NUAK1, PAK3, PDGFRA, PDGFRB, PHKG1, PHKG2, PIP4K2B, pknB, PRKAA1, PRKAA2, PTK2B, RET, RIOK1, RIOK2, RPS6KA2, RPS6KB1, SLK, SRPK3, STK10, STK11, STK17A, STK24, STK3, STK33, STK4, TNIK, TPTEP2-CSNK1E, TTK, TYRO3, ULK1, ULK2, ULK3
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, AIM1, ALK, ANKK1, AURKB, AURKC, BMPR2, C8orf44-SGK3, CAMK1, CAMK1D, CAMK1G, CAMK2D, CAMK2G, CAMK4, CAMKK1, CDK14, CDK16, CDK7, CHEK1, CHUK, CSNK1A1L, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, CSNK2A2, DAPK1, DAPK2, DCLK1, DCLK3, DLK1, DYRK1A, DYRK2, EIF2AK2, EIF2AK4, EPHA6, EPHB1, EPHB6, ERN1, FES, FGFR1, FGFR2, FGFR3, FGR, FLG, FRK, FYN, GCK, GRK1, GRK4, GRK7, HCK, HIPK4, HUNK, ICK, IGF1R, IKBKE, INSR, INSRR, IRAK3, JAK2, KCNH2, LATS1, LATS2, LCK, LYN, MAP2K1, MAP2K1, MAP2K2, MAP2K4, MAP3K11, MAP3K12, MAP3K3, MAP4K3, MAP4K4, MARK2, MARK3, MAST1, MELK, MUSK, MYLK, NIM1K, NTRK1, NTRK2, NUAK2, OSR1, OXSR1, PAK5, PHKA2, PKD1, PKD2, PKN1, PLK4, PRKAB1, PRKAB2, PRKD1, PRKD2, PRKD3, PRPF4, PRPF4B, PTK2, RIPK1, ROCK1, ROCK2, RPS6KA1, RPS6KA3, RPS6KA4, RPS6KA5, SBK1, SGK2, SGK3, SIK2, SNRK, SRC, SRPK1, SRPK2, STK16, STK17B, STK25, STK26, Stk3, STK38, STK38L, STK39, TAOK1, TAOK3, TBK1, TLK1, TLK2, TNK1, TSSK2, TYK2, Ulk3, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL2, AKT2, AURKA, BMPR1B, BRSK1, BRSK2, BTK, BUB1B-PAK6, CAMK2B, CAMKK2, CDC7, CDK1, CDK17, CDK18, CDK4, CDK5, CDKL2, CIT, DCLK2, DDR1, DDR2, DSTYK, DYRK1B, DYRK3, DYRK4, EEF2K, EGFR, EPHA3, EPHA5, EPHA7, EPHB4, FER, FGFR4, GRK5, JAK3, LTK, MAP2K3, MAP2K6, MAP3K15, MAP3K4, MAP3K9, MAPK10, MAPK7, MAPK9, MARK1, MARK4, MATK, MET, MKNK1, MKNK2, MYO3A, MYO3B, NEK2, NEK4, NEK7, NTRK3, PAK4, PAK6, PDK1, PDPK1, PF3D7_0217500, PIM3, PIP5K1A, PKN2, PLK2, PRKCA, PRKCG, PRKCI, PRKCQ, PRKCZ, PTK6, RIOK3, RIPK4, RPS6KA6, SBK3, SIK1, SIK1B, SRC, STK35, TIE1, TNK2, TNKS2, TSSK1B, WEE1
10
(confirmed non-binding)
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Batch Information for HMSL10175-999-5:

HMS LINCS Batch ID: 10175-999-5
Provider:
Provider Batch ID:
Salt: 999
Molecular Formula:
Molecular Weight:
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2016-05-27
Most Recent Update: 2016-12-02